Aging unmasks adverse effects of gestational exposure to methylmercury in rats
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چکیده
منابع مشابه
Aging unmasks adverse effects of gestational exposure to methylmercury in rats.
The consequences of developmental exposure to methylmercury on behavior in aged animals were investigated. Methylmercury exposure was arranged by placing 0, 0.5 or 6.4 ppm Hg in the drinking water of female rats at least 4 weeks before mating and continuing until post-natal (PN) day 16. Brain Hg concentrations in cohorts of low- and high-dose offspring were 0.5 and 9.1 ppm at birth and 0.04 and...
متن کاملGestational exposure to methylmercury retards choice in transition in aging rats.
Developmental exposure to methylmercury has behavioral effects that extend into adulthood and aging. In this study, methylmercury's prolonged effects on the acquisition of choice and sensitivity to changes in reinforcement rates were studied. Pregnant female rats were exposed to drinking water containing 0, 0.5, or 6.4 ppm Hg as methylmercury, resulting in about 40 and 500 microg/kg/day of merc...
متن کاملMethylmercury Exposure and Adverse Cardiovascular Effects in Faroese Whaling Men
BACKGROUND Methylmercury (MeHg), a worldwide contaminant found in fish and seafood, has been linked to an increased risk of cardiovascular mortality. OBJECTIVE We examined 42 Faroese whaling men (30-70 years of age) to assess possible adverse effects within a wide range of MeHg exposures from consumption of pilot whale meat. METHODS We assessed exposure levels from mercury analysis of toena...
متن کاملEffects of gestational exposure to methylmercury and dietary selenium on reinforcement efficacy in adulthood.
It has recently been demonstrated that developmental exposure to methylmercury (MeHg) is associated with perseveration on operant tasks. An understanding of the behavioral mechanisms underlying this phenomenon may improve human testing of MeHg exposures and could provide insight into clinical syndromes that include perseveration as a component. One possible mechanism is that MeHg-induced enhanc...
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ژورنال
عنوان ژورنال: Neurotoxicology and Teratology
سال: 2000
ISSN: 0892-0362
DOI: 10.1016/s0892-0362(00)00107-0